Health Effects
the impacts of long term exposure to poor indoor air quality
Mechanisms of damage
Oxidative Stress:
Oxidative Stress:
Oxidative Stress:
Pollutants generate reactive oxygen species (ROS), leading to oxidative stress and damage to cellular components like DNA, proteins, and lipids. This oxidative damage is a key factor in the development of chronic diseases like cancer and cardiovascular conditions.
Inflammation:
Oxidative Stress:
Oxidative Stress:
Chronic exposure to pollutants triggers inflammatory responses, causing tissue damage and contributing to chronic diseases such as asthma and COPD. Inflammation is a primary mechanism by which pollutants exacerbate these conditions.
Cellular Damage:
Disruption of Cellular Processes:
Disruption of Cellular Processes:
Pollutants directly damage cells, leading to cell death or mutations that can initiate cancer development. Mycotoxins from fungi interfere with RNA synthesis and cause DNA damage, contributing to cancer risk.
Disruption of Cellular Processes:
Disruption of Cellular Processes:
Disruption of Cellular Processes:
Pollutants interfere with normal cellular processes, including energy production, cell signaling, and gene expression. This widespread disruption can lead to metabolic disorders and endocrine system interference, affecting overall health.
Sources
List:
Billions of people still breathe unhealthy air: new WHO data (no date). Available at: https://www.who.int/news/item/04-04-2022-billions-of-people-still-breathe-unhealthy-air-new-who-data (Accessed: 2 July 2024).
Saini, J., Dutta, M., and Marques, G. (2020) ‘A comprehensive review on indoor air quality monitoring systems for enhanced public health’ Sustainable Environment Research, 30(1), p. 6. Available at: https://doi.org/10.1186/s42834-020-0047-y.
Sun, C., et al. (2023) ‘Indoor air quality and its health effects in offices and school buildings in the Yangtze River Delta’ Air Quality, Atmosphere & Health, 16(8), pp. 1571-1586. Available at: https://doi.org/10.1007/s11869-023-01358-5.
Duarte, C.M., Jaremko, Ł., and Jaremko, M. (2020) ‘Hypothesis: Potentially Systemic Impacts of Elevated CO2 on the Human Proteome and Health’ Frontiers in Public Health, 8, p. 543322. Available at: https://doi.org/10.3389/fpubh.2020.543322.
Hypercapnia (no date) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/24808-hypercapnia (Accessed: 2 July 2024).
Kim, Y., et al. (2023) ‘Impact of decreased levels of total CO2 on in-hospital mortality in patients with COVID-19’ Scientific Reports, 13, p. 16717. Available at: https://doi.org/10.1038/s41598-023-41988-4.
Stolp, H. (2022) ‘Developing in a polluted atmosphere: A link between long‐term exposure to elevated atmospheric CO2 and hyperactivity’ The Journal of Physiology, 600(6), pp. 1275-1276. Available at: https://doi.org/10.1113/JP282577.
Souto, G., et al. (2011) ‘Metabolic Acidosis-Induced Insulin Resistance and Cardiovascular Risk’ Metabolic Syndrome and Related Disorders, 9(4), pp. 247-253. Available at: https://doi.org/10.1089/met.2010.0108.
Roh, T., et al. (2021) ‘Indoor Air Quality and Health Outcomes in Employees Working from Home during the COVID-19 Pandemic: A Pilot Study’ Atmosphere, 12(12), p. 1665. Available at: https://doi.org/10.3390/atmos12121665
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